1207064-61-6
Chemical Structure
WAY208466 dihydrochloride
- No. CAS: 1207064-61-6
- Formula:C17H20Cl2FN3O2S
- Molecular Weight:420.33
IUPAC Name: 2-(3-((3-fluorophenyl)sulfonyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-N,N-dimethylethan-1-amine dihydrochloride
InChIKey: BAOHMLBVCLITHA-UHFFFAOYSA-N
SMILES: CN(C)CCN1C=C(S(=O)(C2=CC=CC(F)=C2)=O)C3=CC=CN=C31.[H]Cl.[H]Cl
Biological Activity: WAY 208466 dihydrochloride is a potent and selective 5-HT6 receptor agonist (EC50=7.3 nM for the human 5-HT6 receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex[1]. WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects[2].
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WAY208466 dihydrochloride | 98.43% | WAY 208466 dihydrochloride is a potent and selective 5-HT6 receptor agonist (EC50=7.3 nM for the human 5-HT6 receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex. WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects. | ||||||||||||||||||||
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- [1]. Schechter LE, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]
- [2]. Carr GV, Schechter LE, Lucki I. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology (Berl). 2011 Feb;213(2-3):499-507. [Content Brief]
Keywords
