1214454-56-4
Chemical Structure
Antimalarial agent 11
- CAS No.: 1214454-56-4
- Formula:C25H25F2NO3
- Molecular Weight:425.47
IUPAC Name: 1'-(2-(3,4-difluorophenyl)-2-hydroxyethyl)-3,4-dihydrospiro[benzo[h]chromene-2,4'-piperidin]-4-ol
InChIKey: PILGVBYEWDKGIX-UHFFFAOYSA-N
SMILES: OC(CN1CCC2(CC(O)C3=C(O2)C4=C(C=CC=C4)C=C3)CC1)C5=CC=C(F)C(F)=C5
Biological Activity: Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].
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Antimalarial agent 11 | Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively. | |||||||||||||||||||||
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Keywords
