1219922-30-1
Chemical Structure
(±)-Anatoxin A fumarate
- CAS No.: 1219922-30-1
- Formula:C14H19NO5
- Molecular Weight:281.30
IUPAC Name: 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)ethan-1-one fumarate
InChIKey: ZJSIFVODFDHYJU-WLHGVMLRSA-N
SMILES: CC(C1=CCCC2CCC1N2)=O.O=C(O)/C=C/C(O)=O
Biological Activity: (±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to α4β2- and α7-type nicotinic receptors in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM). (±)-Anatoxin A fumarate has toxic effect on fish[1][2][3][4].
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(±)-Anatoxin A fumarate | (±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to α4β2- and α7-type nicotinic receptors in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM). (±)-Anatoxin A fumarate has toxic effect on fish. | |||||||||||||||||||||
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- [1]. P Thomas, et al. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem. 1993 Jun;60(6):2308-11. [Content Brief]
- [2]. Plata-Calzado C, et al. Assessment of the Effects of Anatoxin-a In Vitro: Cytotoxicity and Uptake. Toxins (Basel). 2024 Dec 13;16(12):541. [Content Brief]
- [3]. Sharples CG, et al. UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci. 2000 Apr 15;20(8):2783-91. [Content Brief]
- [4]. Osswald J, et al. Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss. Toxicon. 2013 Aug;70:162-9. [Content Brief]
Keywords
