126422-57-9
126422-57-9
Chemical Structure
Bis-propargyl-PEG2
- CAS 番号: 126422-57-9
- Formula:C10H14O3
- Molecular Weight:182.22
IUPAC Name: 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)prop-1-yne
InChIKey: ZQNBDEOGKNZIQM-UHFFFAOYSA-N
SMILES: C#CCOCCOCCOCC#C
Biological Activity: Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Bis-propargyl-PEG2 | Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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References
- [1]. Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13(10):3018-30. [Content Brief]
- [2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.
Keywords
