1267949-42-7
Chemical Structure
DW532
- CAS 番号: 1267949-42-7
- Formula:C16H12O6
- Molecular Weight:300.27
IUPAC Name: 7,8-dihydroxy-4-(3-hydroxy-4-methoxyphenyl)-2H-chromen-2-one
InChIKey: IHPLZLMGSYGDMA-UHFFFAOYSA-N
SMILES: O=C1OC=2C(O)=C(O)C=CC2C(=C1)C=3C=CC(OC)=C(O)C3
Biological Activity: DW532 is a dual inhibitor of tubulin and tyrosine kinase, with IC50 values of 4.9 μM and 5.5 μM against EGFR and VEGFR2, respectively, and a KD of 3.6 μM for tubulin. DW532 induces cell cycle arrest at the G2/M phase, triggers cell apoptosis via caspase-related pathways, and inhibits angiogenesis. DW532 can be used for research related to cancers (e.g., breast cancer)[1].
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DW532 | DW532 is a dual inhibitor of tubulin and tyrosine kinase, with IC50 values of 4.9 μM and 5.5 μM against EGFR and VEGFR2, respectively, and a KD of 3.6 μM for tubulin. DW532 induces cell cycle arrest at the G2/M phase, triggers cell apoptosis via caspase-related pathways, and inhibits angiogenesis. DW532 can be used for research related to cancers (e.g., breast cancer). | |||||||||||||||||||||
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Keywords
