128007-31-8
Chemical Structure
Arvanil
Synonym(s): N-Vanillylarachidonamide
- CAS No.: 128007-31-8
- Formula:C28H41NO3
- Molecular Weight:439.63
IUPAC Name: (5Z,8Z,11Z,14Z)-N-(4-hydroxy-3-methoxybenzyl)icosa-5,8,11,14-tetraenamide
InChIKey: QVLMCRFQGHWOPM-ZKWNWVNESA-N
SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCC1=CC=C(O)C(OC)=C1)=O
Biological Activity: Arvanil (N-Vanillylarachidonamide) is a mixed agonist of CB1 and TRPV1 receptors. Arvanil downregulates CD25, HLA-DR, CD134/OX40, blocks G1/S phase transition, and induces phosphorylation of Akt. Arvanil does not induce apoptosis in cells. Arvanil inhibits lymphocyte activation and ameliorates autoimmune encephalomyelitis. Arvanil can be used in research related to Huntington's disease, vomiting, and multiple sclerosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Arvanil | 99.1% | Arvanil (N-Vanillylarachidonamide) is a mixed agonist of CB1 and TRPV1 receptors. Arvanil downregulates CD25, HLA-DR, CD134/OX40, blocks G1/S phase transition, and induces phosphorylation of Akt. Arvanil does not induce apoptosis in cells. Arvanil inhibits lymphocyte activation and ameliorates autoimmune encephalomyelitis. Arvanil can be used in research related to Huntington's disease, vomiting, and multiple sclerosis. | ||||||||||||||||||||
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- [1]. de Lago E, et al. Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease. Brain Res. 2005;1050(1-2):210-216. [Content Brief]
- [2]. Sharkey KA, et al. Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret. Eur J Neurosci. 2007;25(9):2773-2782. [Content Brief]
- [3]. Malfitano AM, et al. Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. J Neuroimmunol. 2006;171(1-2):110-119. [Content Brief]
Keywords
