128723-16-0
Chemical Structure
Calcitriol-d3
Synonym(s): 1,25-Dihydroxyvitamin D3-d3
- CAS No.: 128723-16-0
- Formula:C27H41D3O3
- Molecular Weight:419.65
IUPAC Name: (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene-1-d)-4-(methylene-d2)cyclohexane-1,3-diol
InChIKey: GMRQFYUYWCNGIN-POLIPXRRSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C([2H])=C3\C([C@H](C[C@@H](C3)O)O)=C([2H])/[2H]
Biological Activity: Calcitriol-d3 is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist[2][3][4][5].
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Calcitriol-d3 | Calcitriol-d3 is the deuterium labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. | |||||||||||||||||||||
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Calcitriol (Standard) | 99.94% | Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. | ||||||||||||||||||||
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Calcitriolc | 1α,25-Dihydroxyvitamin D3-(23,24,25,26,27-13C5) solution is the 13C labeled 1α,25-Dihydroxyvitamin D3. | |||||||||||||||||||||
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Calcitriol-d6 | 99.27% | Calcitriol-d6 is the deuterium labeled Calcitriol. Calcitriol is the active metabolite of vitamin D3 and an agonist of the vitamin D receptor (VDR). | ||||||||||||||||||||
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Calcitriol-13C3 | 97.0% | Calcitriol-13C3 is the 13C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. | ||||||||||||||||||||
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Calcitriol-d9 | Calcitriol-d9 (1,25-Dihydroxyvitamin D3-d9) is the deuterium labeled Calcitriol (HY-10002). Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. | |||||||||||||||||||||
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Calcitriol | 99.94% | Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Wang G, et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014;22(5-6):301-9. [Content Brief]
- [3]. Santos-Martínez N, et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 2914:230. [Content Brief]
- [4]. Dong J, et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul84(1):54-63. [Content Brief]
- [5]. Chou CL, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 1610(3):e0119843. [Content Brief]
