130370-59-1
Chemical Structure
GI-129471
- CAS No.: 130370-59-1
- Formula:C25H33N3O4S
- Molecular Weight:471.61
IUPAC Name: (2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-2-((phenylthio)methyl)succinamide
InChIKey: UBFGIEDUTRCMEQ-FSSWDIPSSA-N
SMILES: ONC([C@@H](CSC1=CC=CC=C1)[C@@H](CC(C)C)C(N[C@H](C(NC)=O)CC2=CC=CC=C2)=O)=O
Biological Activity: GI-129471 is a MMP inhibitor. GI-129471 exhibits inhibitory activity against cancer cell invasion. GI-129471 can completely block the enhanced production of IgE and IgG1 by mouse B cells induced by rat mast cell protease-I (RMCP-I). GI-129471 can be used for the study of cancer and mast cell chymase-regulated immunological processes[1][2].
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GI-129471 | GI-129471 is a MMP inhibitor. GI-129471 exhibits inhibitory activity against cancer cell invasion. GI-129471 can completely block the enhanced production of IgE and IgG1 by mouse B cells induced by rat mast cell protease-I (RMCP-I). GI-129471 can be used for the study of cancer and mast cell chymase-regulated immunological processes. | |||||||||||||||||||||
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- [1]. Kempen I, et al. 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo. Br J Cancer. 2003 Apr 7;88(7):1111-8. [Content Brief]
- [2]. Yoshikawa T, et al. Rat mast cell protease-I enhances immunoglobulin E production by mouse B cells stimulated with interleukin-4. Immunology. 2001 Nov;104(3):333-40. [Content Brief]
Keywords
