13129-80-1
Chemical Structure
Stercobilin hydrochloride (mixture of isomers)
- CAS No.: 13129-80-1
- Formula:C33H47ClN4O6
- Molecular Weight:631.20
InChIKey: WPZBPYPTZWWARY-JRFVQKEISA-N
SMILES: OC(CCC(C(C)=C(N1)C[C@H]2[C@@H]([C@H](C(N2)=O)C)CC)=C1/C=C3C(CCC(O)=O)=C(C(C[C@H]4[C@@H]([C@H](C(N4)=O)CC)C)=N/3)C)=O.Cl
Biological Activity:
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections[1][2].
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Stercobilin hydrochloride (mixture of isomers) | Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections. |
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- [1]. Sanada S, et al. Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice. Sci Rep. 2020 Apr 15;10(1):6479. [Content Brief]
- [2]. McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. Biochem J. 1996 Dec 1;320 ( Pt 2)(Pt 2):681-6. [Content Brief]
