132-20-7
Chemical Structure
Pheniramine maleate
Synonym(s): Prophenpyridamine maleate; Tripoton maleate
- CAS No.: 132-20-7
- Formula:C20H24N2O4
- Molecular Weight:356.42
IUPAC Name: N,N-dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate
InChIKey: SSOXZAQUVINQSA-BTJKTKAUSA-N
SMILES: CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.O=C(O)/C=C\C(O)=O
Biological Activity: Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects[1][2][3][4].
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Pheniramine maleate | 99.94% | Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects. | ||||||||||||||||||||
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Pheniramine maleate (Standard) | ≥98% | Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects. | ||||||||||||||||||||
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Pheniramine-d6 maleate | Pheniramine-d6 (maleate) is the deuterium labeled Pheniramine maleate. Pheniramine Maleate ia an antihistamine and vasoconstrictor. | |||||||||||||||||||||
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- [1]. Sharma A, et al. Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. Curr Drug Metab. 2003 Apr;4(2):105-29. [Content Brief]
- [2]. Brown RD, et al. Alpha 1-adrenergic and H1-histamine receptor control of intracellular Ca2+ in a muscle cell line: the influence of prior agonist exposure on receptor responsiveness. Mol Pharmacol. 1986 Jun;29(6):531-9. [Content Brief]
- [3]. Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72. [Content Brief]
- [4]. Hung CH, et al. Spinal anesthesia with diphenhydramine and pheniramine in rats. Eur J Pharmacol. 2011 Dec 30;673(1-3):20-4. [Content Brief]
