1326750-61-1
Chemical Structure
MHY219
- CAS No.: 1326750-61-1
- Formula:C20H25N3O3
- Molecular Weight:355.43
IUPAC Name: N1-hydroxy-N8-(4-(phenylamino)phenyl)octanediamide
InChIKey: FXKGVLUVYSWHHN-UHFFFAOYSA-N
SMILES: O=C(NO)CCCCCCC(NC1=CC=C(NC2=CC=CC=C2)C=C1)=O
Biological Activity: MHY219 is a histone deacetylase (HDAC) inhibitor with an IC50 of 0.276 μM. MHY219 inhibits total HDAC enzyme activity, increases histone H3 and H4 hyperacetylation. MHY219 induces cance cells phase arrest, apoptosis and inhibits proliferationin. MHY219 increases cleavage of PARP, Bax, cytochrome c levels, androgen receptor expression and decreases Bcl-2 expression. MHY219 can be used for the research of prostate cancer[1].
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MHY219 | MHY219 is a histone deacetylase (HDAC) inhibitor with an IC50 of 0.276 μM. MHY219 inhibits total HDAC enzyme activity, increases histone H3 and H4 hyperacetylation. MHY219 induces cance cells phase arrest, apoptosis and inhibits proliferationin. MHY219 increases cleavage of PARP, Bax, cytochrome c levels, androgen receptor expression and decreases Bcl-2 expression. MHY219 can be used for the research of prostate cancer. | |||||||||||||||||||||
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Keywords
