132971-59-6
132971-59-6
Chemical Structure
Cytogenin
Synonym(s): Antibiotic MI 43-37F11
- CAS No.: 132971-59-6
- Formula:C11H10O5
- Molecular Weight:222.19
IUPAC Name: 8-hydroxy-3-(hydroxymethyl)-6-methoxy-1H-isochromen-1-one
InChIKey: CAWNOJXNAUEIGB-UHFFFAOYSA-N
SMILES: O=C1OC(CO)=CC2=C1C(O)=CC(OC)=C2
Biological Activity: Cytogenin (Antibiotic MI 43-37F11) is an orally active antineoplastic antibiotic. Cytogenin regulates the inflammatory cytokine, reduces the levels of iNOS, NO and IL-6 in mouse macrophages, and exhibits antidiabetic efficacy in mice. Cytogenin inhibits growth of Ehrlich ascites tumor in mouse model[1][2][3].
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Cytogenin | Cytogenin (Antibiotic MI 43-37F11) is an orally active antineoplastic antibiotic. Cytogenin regulates the inflammatory cytokine, reduces the levels of iNOS, NO and IL-6 in mouse macrophages, and exhibits antidiabetic efficacy in mice. Cytogenin inhibits growth of Ehrlich ascites tumor in mouse model. | |||||||||||||||||||||
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References
- [1]. Kumagai H, et al., Biosynthesis of antitumor antibiotic, cytogenin. J Antibiot (Tokyo). 1994 Apr;47(4):440-6. [Content Brief]
- [2]. Kumagai H, et al., Cytogenin, a novel antitumor substance. J Antibiot (Tokyo). 1990 Nov;43(11):1505-7. [Content Brief]
- [3]. Kumagai H, et al., Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice. J Antibiot (Tokyo). 2005 Mar;58(3):202-5. [Content Brief]
Keywords
