133690-62-7
133690-62-7
Chemical Structure
SC-51316
- CAS No.: 133690-62-7
- Formula:C24H29N7O
- Molecular Weight:431.53
IUPAC Name: 4-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,5-dibutyl-2,4-dihydro-3H-1,2,4-triazol-3-one
InChIKey: STODEQQYGGTXOS-UHFFFAOYSA-N
SMILES: O=C1N(CCCC)N=C(CCCC)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2
Biological Activity: SC-51316 is an oral active angiotensin II receptor antagonist with the IC50 values of 3.6 and 5.1 nM in rat adrenal cortical and rat uterine membrane, respectively. SC-51316 shows antihypertensive activity in vivo and in vitro[1][2].
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SC-51316 | SC-51316 is an oral active angiotensin II receptor antagonist with the IC50 values of 3.6 and 5.1 nM in rat adrenal cortical and rat uterine membrane, respectively. SC-51316 shows antihypertensive activity in vivo and in vitro. | |||||||||||||||||||||
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References
- [1]. Olins GM, et al. In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC-51316. J Pharmacol Exp Ther. 1992;261(3):1037-1043. [Content Brief]
- [2]. Olins GM, et al. In vivo pharmacology of SC-51316, a nonpeptidic angiotensin II receptor antagonist. Am J Hypertens. 1993;6(7 Pt 1):619-625. [Content Brief]
Keywords
