134186-26-8
Chemical Structure
KF-14124
- CAS No.: 134186-26-8
- Formula:C19H27N3O5S
- Molecular Weight:409.50
IUPAC Name: (3S,3aS,6S,6aR)-6-(4-(3-(phenylthio)propyl)piperazin-1-yl)hexahydrofuro[3,2-b]furan-3-yl nitrate
InChIKey: IHHFECHILHHROD-INDMIFKZSA-N
SMILES: O=[N+]([O-])O[C@@H]1[C@](OC[C@@H]2N3CCN(CCCSC4=CC=CC=C4)CC3)([H])[C@]2([H])OC1
Biological Activity: KF-14124, an orally active organic nitrate, a long-acting vasodilator with highly selective venous dilating action. KF-14124 is used in the study for angina pectoris. KF-14124 shows good oral inhibition of lysine-vasopressin induced coronary vasospasm with a potency[1][2].
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KF-14124 | KF-14124, an orally active organic nitrate, a long-acting vasodilator with highly selective venous dilating action. KF-14124 is used in the study for angina pectoris. KF-14124 shows good oral inhibition of lysine-vasopressin induced coronary vasospasm with a potency. | |||||||||||||||||||||
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- [1]. 1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1091-9. [Content Brief]
- [2]. Giorgio Bertolini, et al. Overview: Recent Advances in Organic Nitrates. Current Opinion on Therapeutic Patents Volume 3, 1993 - Issue 10.
Keywords
