1346169-63-8
Chemical Structure
SA57
- CAS No.: 1346169-63-8
- Formula:C17H23ClN2O3
- Molecular Weight:338.83
IUPAC Name: 2-(methylamino)-2-oxoethyl 4-(4-chlorophenethyl)piperidine-1-carboxylate
InChIKey: JFSSVCSHPDLFCM-UHFFFAOYSA-N
SMILES: O=C(N1CCC(CCC2=CC=C(Cl)C=C2)CC1)OCC(NC)=O
Biological Activity: SA57 is a potent, selective FAAH inhibitor with IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC50s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 of 850 nM), but not other brain serine hydrolases[1][2].
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SA57 | SA57 is a potent, selective FAAH inhibitor with IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC50s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 of 850 nM), but not other brain serine hydrolases. | |||||||||||||||||||||
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- [1]. Niphakis MJ, et al. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci. 2012 May 16;3(5):418-26. [Content Brief]
- [2]. Owens RA, et al. Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice. J Pharmacol Exp Ther. 2016 Aug;358(2):306-14. [Content Brief]
Keywords
