1346265-80-2
Chemical Structure
BRN-103
- CAS No.: 1346265-80-2
- Formula:C24H25ClN4O
- Molecular Weight:420.94
IUPAC Name: 2-((1-benzylpiperidin-4-yl)amino)-N-(3-chlorophenyl)nicotinamide
InChIKey: FJLKVQYKXSXIPA-UHFFFAOYSA-N
SMILES: O=C(NC=1C=CC=C(Cl)C1)C2=CC=CN=C2NC3CCN(CC=4C=CC=CC4)CC3
Biological Activity: BRN-103 is a nicotinamide derivative and an inhibitor of the VEGF/VEGFR2 angiogenesis signaling pathway. BRN-103 concentration-dependently inhibits VEGF-induced migration, proliferation and capillary-like tube formation of HUVECs, and suppresses microvascular sprouting of ex vivo aortic rings. BRN-103 inhibits VEGF-induced phosphorylation of VEGFR2 Tyr1175, as well as the downstream phosphorylation of AKT Ser473 and eNOS Ser1172, while exerting a weak inhibitory effect on ERK phosphorylation. BRN-103 can be used in studies related to VEGF/VEGFR2 signaling and angiogenesis[1].
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BRN-103 | BRN-103 is a nicotinamide derivative and an inhibitor of the VEGF/VEGFR2 angiogenesis signaling pathway. BRN-103 concentration-dependently inhibits VEGF-induced migration, proliferation and capillary-like tube formation of HUVECs, and suppresses microvascular sprouting of ex vivo aortic rings. BRN-103 inhibits VEGF-induced phosphorylation of VEGFR2 Tyr1175, as well as the downstream phosphorylation of AKT Ser473 and eNOS Ser1172, while exerting a weak inhibitory effect on ERK phosphorylation. BRN-103 can be used in studies related to VEGF/VEGFR2 signaling and angiogenesis. | |||||||||||||||||||||
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