1350296-21-7
1350296-21-7
Chemical Structure
CM304 free base
Synonym(s): FTC-146
- CAS No.: 1350296-21-7
- Formula:C18H25FN2OS
- Molecular Weight:336.47
IUPAC Name: 3-(2-(azepan-1-yl)ethyl)-6-(3-fluoropropyl)benzo[d]thiazol-2(3H)-one
InChIKey: DNGYIBDXSUNKMV-UHFFFAOYSA-N
SMILES: O=C1SC2=CC(CCCF)=CC=C2N1CCN3CCCCCC3
Biological Activity: CM304 free base (FTC-146) is a potent S1R antagonist. CM304 free base enhances the antinociceptive effects of the cannabinoid receptor agonists. CM304 free base inhibits convulsions in rats[1][2].
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CM304 free base | CM304 free base (FTC-146) is a potent S1R antagonist. CM304 free base enhances the antinociceptive effects of the cannabinoid receptor agonists. CM304 free base inhibits convulsions in rats. | |||||||||||||||||||||
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References
- [1]. Avery BA, et al. Quantification of highly selective sigma-1 receptor antagonist CM304 using liquid chromatography tandem mass spectrometry and its application to a pre-clinical pharmacokinetic study. Drug Test Anal. 2017 Aug;9(8):1236-1242. [Content Brief]
- [2]. Patel A, et al. The Sigma1 Receptor Antagonist CM304 Enhances the Antinociceptive Effects of the Cannabinoid Receptor Agonists, but not Mu‐Opioid Receptor Full Agonists in Mice[J]. The FASEB Journal, 2020, 34(S1): 1-1.
Keywords
