1351452-80-6
Chemical Structure
NRX-204647
- CAS No.: 1351452-80-6
- Formula:C24H27NO3
- Molecular Weight:377.48
IUPAC Name: 4-((1E,3Z)-3-(hydroxyimino)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid
InChIKey: DKMAOOMRQCCGEO-LOOVLXKESA-N
SMILES: O=C(C1=CC=C(C=C1)/C=C/C(C2=CC=C3C(C)(CCC(C)(C3=C2)C)C)=N/O)O
Biological Activity: NRX-204647 is a potent activator of retinoic acid nuclear (RAR) with higher specificity than that to RAR and RAR. NRX-204647 can inhibit bone formation. NRX-204647 significantly reduces bone volume/tissue volume (BV/TV). NRX-204647 can be studied in anti-cancer research[1][2].
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NRX-204647 | NRX-204647 is a potent activator of retinoic acid nuclear (RAR) with higher specificity than that to RAR and RAR. NRX-204647 can inhibit bone formation. NRX-204647 significantly reduces bone volume/tissue volume (BV/TV). NRX-204647 can be studied in anti-cancer research. | |||||||||||||||||||||
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- [1]. Uchibe, K., et al., (2017). Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(5), 1096-1105. [Content Brief]
- [2]. Garcia, S. A., et al., (2020). Understanding the Action of RARγ Agonists on Human Osteochondroma Explants. International journal of molecular sciences, 21(8), 2686. [Content Brief]
Keywords
