1356922-05-8
1356922-05-8
Chemical Structure
Bimagrumab
Synonym(s): Anti-ACVR2B Reference Antibody; BYM338
- CAS No.: 1356922-05-8
- Formula:N/A
- Molecular Weight:(142.78 kDa)
IUPAC Name: dimethyl (6E,13E)-5,12-dihydrocycloocta[1,2-b:5,6-b']diindole-6,13-dicarboxylate
SMILES: [Bimagrumab]
Biological Activity: Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness[1][2].
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Bimagrumab | 99.31% | Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness. | ||||||||||||||||||||
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References
- [1]. Heymsfield SB, et, al. Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial. JAMA Netw Open. 2021 Jan 4;4(1):e2033457. [Content Brief]
- [2]. Lach-Trifilieff E, et, al. An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy. Mol Cell Biol. 2014 Feb;34(4):606-18. [Content Brief]
Keywords
