1358617-36-3
1358617-36-3
Chemical Structure
BC-1901S
- CAS No.: 1358617-36-3
- Formula:C23H22ClFN4O
- Molecular Weight:424.90
InChIKey: BSBMHQSETMLEDQ-UHFFFAOYSA-N
SMILES: O=C(C1CCN(CC1)C2=NC(C3=CC(C)=CC=C3)=NC=C2)NC4=CC=C(C(Cl)=C4)F
Biological Activity: BC-1901S is a proteasome-independent NRF2 activator and stabilizer. BC-1901S binds to DCAF1 (E3 ligase subunit) and disrupts NRF2/DCAF1 interaction, and activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. BC-1901S shows anti-inflammatory effect in a murine model of LPS-induced acute lung injury[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BC-1901S | 99.81% | BC-1901S is a proteasome-independent NRF2 activator and stabilizer. BC-1901S binds to DCAF1 (E3 ligase subunit) and disrupts NRF2/DCAF1 interaction, and activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. BC-1901S shows anti-inflammatory effect in a murine model of LPS-induced acute lung injury. | ||||||||||||||||||||
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References
Keywords
