1372688-55-5
Chemical Structure
Androgen receptor degrader-6
- CAS No.: 1372688-55-5
- Formula:C17H20N2O7S
- Molecular Weight:396.41
InChIKey: UMUHWUNEIJQCMH-UHFFFAOYSA-N
SMILES: CN(S(C)(=O)=O)C1=CC=C([N+]([O-])=O)C=C1OCC2=CC(OC)=CC=C2OC
Biological Activity: Androgen receptor degrader-6 is a blood-brain barrier-permeable AR degrader. Androgen receptor degrader-6 inhibits the chaperone activity of HSP27 and disrupts the HSP27-AR complex. Androgen receptor degrader-6 promotes the degradation of wild-type and mutant AR, reduces AR protein levels, and inhibits the growth of glioblastoma cells. Androgen receptor degrader-6 can be used in glioblastoma research[1].
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Androgen receptor degrader-6 | Androgen receptor degrader-6 is a blood-brain barrier-permeable AR degrader. Androgen receptor degrader-6 inhibits the chaperone activity of HSP27 and disrupts the HSP27-AR complex. Androgen receptor degrader-6 promotes the degradation of wild-type and mutant AR, reduces AR protein levels, and inhibits the growth of glioblastoma cells. Androgen receptor degrader-6 can be used in glioblastoma research. | |||||||||||||||||||||
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Keywords
