138620-17-4
138620-17-4
Chemical Structure
ZD-6888 hydrochloride
Synonym(s): ICI-D 6888 hydrochloride
- CAS No.: 138620-17-4
- Formula:C25H26ClN5O
- Molecular Weight:447.96
IUPAC Name: 4-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methoxy)-2-ethyl-5,6,7,8-tetrahydroquinoline hydrochloride
InChIKey: RPRNBLHRKYAXSM-UHFFFAOYSA-N
SMILES: CCC1=NC2=C(CCCC2)C(OCC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)=C1.Cl
Biological Activity: ZD-6888 hydrochloride (ICI-D 6888 hydrochloride) is an antagonist for angiotensin II, which competitively inhibits the angiotensin II-mediated release of renin, affects the renal structure and function[1].
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ZD-6888 hydrochloride | ZD-6888 hydrochloride (ICI-D 6888 hydrochloride) is an antagonist for angiotensin II, which competitively inhibits the angiotensin II-mediated release of renin, affects the renal structure and function. | |||||||||||||||||||||
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References
- [1]. Jackson DG, et al., Histopathological and ultrastructural changes in the juxtaglomerular apparatus of the rat following administration of ZENECA ZD6888 (2-ethyl-5,6,7,8-tetrahydro-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)- methoxy]quinoline), an angiotensin II antagonist. Toxicol Pathol. 1995 Jan-Feb;23(1):7-15. [Content Brief]
Keywords
