139051-89-1
Chemical Structure
AQ-RA 721
- CAS No.: 139051-89-1
- Formula:C22H23N3O2
- Molecular Weight:361.44
IUPAC Name: 6-oxo-N-(quinuclidin-3-yl)-6,11-dihydro-5H-dibenzo[b,e]azepine-11-carboxamide
InChIKey: UDOYPNBXGCVNFY-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C12)C3=CC=CC=C3NC2=O)NC4CN5CCC4CC5
Biological Activity: AQ-RA 721 is a muscarinic receptor antagonist with differential affinity for the m4 and M2 sites, which can be used to characterize muscarinic receptor subtypes. Other muscarinic receptor antagonists have differential affinity for the M1 (rat cerebral cortex), M2 (rat heart), M3 (rat submandibular gland), m4 (receptor expressed in Chinese hamster ovary cells transfected with CHO), and guinea pig uterine smooth muscle at the muscarinic binding site[1].
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AQ-RA 721 | AQ-RA 721 is a muscarinic receptor antagonist with differential affinity for the m4 and M2 sites, which can be used to characterize muscarinic receptor subtypes. Other muscarinic receptor antagonists have differential affinity for the M1 (rat cerebral cortex), M2 (rat heart), M3 (rat submandibular gland), m4 (receptor expressed in Chinese hamster ovary cells transfected with CHO), and guinea pig uterine smooth muscle at the muscarinic binding site. | |||||||||||||||||||||
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Keywords
