1397683-26-9
Chemical Structure
BACE1-IN-13
- CAS No.: 1397683-26-9
- Formula:C20H17FN8O2
- Molecular Weight:420.40
IUPAC Name: (R)-N-(3-(4-amino-2-cyano-6-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-6-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide
InChIKey: ITBUOSMBIYYJMH-FQEVSTJZSA-N
SMILES: C[C@@]1(C2=CC(NC(C3=NC=C(OC)N=C3)=O)=CC=C2F)CN4C(C(N)=N1)=CC(C#N)=N4
Biological Activity: BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BACE1-IN-13 | BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
