141575-50-0
Chemical Structure
Vedaclidine
- CAS 番号: 141575-50-0
- Formula:C13H21N3S2
- Molecular Weight:283.46
InChIKey: WZZPXVURFDJHGI-LLVKDONJSA-N
SMILES: CCCCSC1=NSN=C1[C@H]2C3CCN(CC3)C2
Biological Activity: Vedaclidine is an orally active muscarinic acetylcholine receptor (mAChR) modulator with mixed receptor activity, which activates muscarinic M2 and M4 receptors and blocks muscarinic M1, M3 and M5 receptors. Vedaclidine exerts its activity through interaction with spinal M4 muscarinic receptors, and does not induce hypothermia or excessive salivation. Vedaclidine can be used in research related to pain, neuropathic pain and inflammatory pain states[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Vedaclidine | Vedaclidine is an orally active muscarinic acetylcholine receptor (mAChR) modulator with mixed receptor activity, which activates muscarinic M2 and M4 receptors and blocks muscarinic M1, M3 and M5 receptors. Vedaclidine exerts its activity through interaction with spinal M4 muscarinic receptors, and does not induce hypothermia or excessive salivation. Vedaclidine can be used in research related to pain, neuropathic pain and inflammatory pain states. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
[1]. Eglen RM, et al. Muscarinic receptor ligands and their therapeutic potential. Curr Opin Chem Biol. 1999 Aug;3(4):426-32.
[Content Brief] - [2]. Shannon HE, et al. Antihyperalgesic effects of the muscarinic receptor ligand vedaclidine in models involving central sensitization in rats. Pain. 2001;93(3):221-227. [Content Brief]
Keywords
