141968-19-6
Chemical Structure
D-NAME
Synonym(s): NG-Nitro-D-arginine methyl ester
- CAS No.: 141968-19-6
- Formula:C7H15N5O4
- Molecular Weight:233.23
IUPAC Name: methyl Nw-nitro-D-argininate
InChIKey: KCWZGJVSDFYRIX-RXMQYKEDSA-N
SMILES: N[C@H](CCCNC(N[N+]([O-])=O)=N)C(OC)=O
Biological Activity: D-NAME (NG-Nitro-D-arginine methyl ester) is an orally active enantiomer of L-NAME (HY-18729). D-NAME inhibits Nitric oxide synthase activity in myocardium and aorta (Note: D-NAME was once classified as an inactive substance and used as a negative control in nitric oxide synthase inhibition studies), induces increases in systolic blood pressure and mean arterial blood pressure, reduces mesenteric arterial conductance, elevates the ratio of left ventricular weight to body weight, induces myocardial fibrosis, increases the cross-sectional area of aortic wall, enhances mesenteric vasodilation induced by nitrovasodilators, and releases nitric oxide via its guanidino nitro group. D-NAME has no effect on ovalbumin-induced pulmonary eosinophilia in sensitized mice. D-NAME can be used in hypertension-related research[1][2][3].
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D-NAME | D-NAME (NG-Nitro-D-arginine methyl ester) is an orally active enantiomer of L-NAME (HY-18729). D-NAME inhibits Nitric oxide synthase activity in myocardium and aorta (Note: D-NAME was once classified as an inactive substance and used as a negative control in nitric oxide synthase inhibition studies), induces increases in systolic blood pressure and mean arterial blood pressure, reduces mesenteric arterial conductance, elevates the ratio of left ventricular weight to body weight, induces myocardial fibrosis, increases the cross-sectional area of aortic wall, enhances mesenteric vasodilation induced by nitrovasodilators, and releases nitric oxide via its guanidino nitro group. D-NAME has no effect on ovalbumin-induced pulmonary eosinophilia in sensitized mice. D-NAME can be used in hypertension-related research. | |||||||||||||||||||||
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References
- [1]. Babál P, et al. Long-term administration of D-NAME induces hemodynamic and structural changes in the cardiovascular system. Physiological research. 2000;49(1):47-54.
- [2]. Feder LS, et al. Role of nitric oxide on eosinophilic lung inflammation in allergic mice. American journal of respiratory cell and molecular biology. 1997 Oct;17(4):436-42.
- [3]. Liu T, et al. L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation. Redox biology. 2019 Sep;26:101238.
