142609-62-9
Chemical Structure
MiADMSA
Synonym(s): Monoisoamyl meso-2,3-dimercaptosuccinic acid
- CAS No.: 142609-62-9
- Formula:C9H16O4S2
- Molecular Weight:252.34
IUPAC Name: (2R,3S)-4-(isopentyloxy)-2,3-dimercapto-4-oxobutanoic acid
InChIKey: RIBYSYWXWXMDSW-NKWVEPMBSA-N
SMILES: [C@H](C(OCCC(C)C)=O)([C@@H](C(O)=O)S)S
Biological Activity: MiADMSA (Monoisoamyl meso-2,3-dimercaptosuccinic acid) is an orally active thiol chelator that can effectively remove heavy metals such as arsenic and lead from the body of animals. Arsenic binds with two vicinal sulfhydryl groups available in MiADMSA leading to marked reduction in body arsenic burden and also marked reduction in various oxidative stress parameters and antioxidant enzymes like-ROS, nitrite, TBARS, GSH, SOD and catalase. MiADMSA attenuates urinary bladder carcinogenesis, protects against oxidative stress, ameliorates copper-induced histopathology, reverses neurotoxicity, and is safe in animals. MiADMSA can be used in studies of bladder cancer, arsenic, and lead-induced developmental neurotoxicity[1][2][3][4][5][6].
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MiADMSA | MiADMSA (Monoisoamyl meso-2,3-dimercaptosuccinic acid) is an orally active thiol chelator that can effectively remove heavy metals such as arsenic and lead from the body of animals. Arsenic binds with two vicinal sulfhydryl groups available in MiADMSA leading to marked reduction in body arsenic burden and also marked reduction in various oxidative stress parameters and antioxidant enzymes like-ROS, nitrite, TBARS, GSH, SOD and catalase. MiADMSA attenuates urinary bladder carcinogenesis, protects against oxidative stress, ameliorates copper-induced histopathology, reverses neurotoxicity, and is safe in animals. MiADMSA can be used in studies of bladder cancer, arsenic, and lead-induced developmental neurotoxicity. | |||||||||||||||||||||
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- [1]. Sathua K, et al. MiADMSA ameliorate arsenic induced urinary bladder carcinogenesis in vivo and in vitro. Biomed Pharmacother. 2020;128:110257. [Content Brief]
- [2]. Dwivedi N, et al. MiADMSA reverses impaired mitochondrial energy metabolism and neuronal apoptotic cell death after arsenic exposure in rats. Toxicol Appl Pharmacol. 2011;256(3):241-248. [Content Brief]
- [3]. Flora SJ, et al. Monoisoamyl 2, 3-dimercaptosuccinic acid (MiADMSA) demonstrates higher efficacy by oral route in reversing arsenic toxicity: a pharmacokinetic approach. Basic Clin Pharmacol Toxicol. 2012;110(5):449-459. [Content Brief]
- [4]. Patwa J, et al. MiADMSA abrogates chronic copper-induced hepatic and immunological changes in Sprague Dawley rats. Food Chem Toxicol. 2020;145:111692. [Content Brief]
- [5]. Flora SJ, et al. Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects. Biol Trace Elem Res. 2007;120(1-3):235-247. [Content Brief]
- [6]. Sannadi S, et al. Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA) for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain. Int J Dev Neurosci. 2013;31(7):586-597. [Content Brief]
Keywords
