1428789-03-0
Chemical Structure
Api137
- CAS No.: 1428789-03-0
- Formula:C104H171N37O22
- Molecular Weight:2291.71
SMILES: O=C([C@@H](/N=C(N(C)C)/N(C)C)CCCN)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N4[C@H](C(N5[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC6)=O)CC7=CNC=N7)=O)CCC5)=O)CCC4)=O)CCCNC(N)=N)=O)CCC3)=O)CCCNC(N)=N)=O)CCC2)=O)[C@H](CC)C)=O)CC8=CC=C(O)C=C8)=O)C(C)C)=O)CCC1)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O
Biological Activity: Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain[1][2].
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Api137 | Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain. | |||||||||||||||||||||
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- [1]. Florin T, et, al. An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24(9):752-757. [Content Brief]
- [2]. Graf M, et, al. Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery. Adv Exp Med Biol. 2019:1117:73-89. [Content Brief]
Keywords
