1430210-54-0
1430210-54-0
Chemical Structure
ZY12201
- CAS No.: 1430210-54-0
- Formula:C31H31FN4O3S
- Molecular Weight:558.67
InChIKey: ZRQBEFYILDBORB-UHFFFAOYSA-N
SMILES: FC1=CC=C(N2C(SCCOC3=CC=C(N4C=NC=C4)C=C3)=NC=C2C(C)(C)C5=CC=C(C(OC)=C5)OC)C=C1
Biological Activity: ZY12201 is a selective and orally active TGR5 agonist and pan-CYP inhibitor. ZY12201 lowers glucose levels. ZY12201 induces enzymes regulated through Aryl Hydrocarbon Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor. ZY12201 can be used for the research of type 2 diabetes[1][2].
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ZY12201 | ZY12201 is a selective and orally active TGR5 agonist and pan-CYP inhibitor. ZY12201 lowers glucose levels. ZY12201 induces enzymes regulated through Aryl Hydrocarbon Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor. ZY12201 can be used for the research of type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Joshi, VM, et al. Practical and Efficient Synthesis of 2-Thio-imidazole derivative - ZY12201: A Potent TGR5 Agonist. Org. Process Res. Dev. 2020; 24(8):1508-1514.
- [2]. Aluri KC, et al. Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping. Clin Transl Sci. 2024;17(3):e13746. [Content Brief]
Keywords
