1431641-29-0
1431641-29-0
Chemical Structure
ADX71743
- CAS No.: 1431641-29-0
- Formula:C17H19NO2
- Molecular Weight:269.34
IUPAC Name: 6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydrobenzo[d]oxazol-4(5H)-one
InChIKey: CPKZCQHJDFSOJT-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC(CC)=N2)CC(C3=C(C=C(C)C=C3)C)C1
Biological Activity: ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 can cross the blood-brain barrier (BBB) and possesses anxiolytic activity.[1][2].
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ADX71743 | 99.46% | ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 can cross the blood-brain barrier (BBB) and possesses anxiolytic activity.. | ||||||||||||||||||||
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References
- [1]. Rebecca Klar, et al. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. J Neurosci. 2015 May 13;35(19):7600-15. [Content Brief]
- [2]. Mikhail Kalinichev , et al. ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and in Vivo Characterization. Pharmacol Exp Ther. 2013 Mar;344(3):624-36. [Content Brief]
Keywords
