1434047-61-6
1434047-61-6
Chemical Structure
VMY-2-95
- CAS No.: 1434047-61-6
- Formula:C17H16N2O
- Molecular Weight:264.32
IUPAC Name: (S)-3-(azetidin-2-ylmethoxy)-5-(phenylethynyl)pyridine
InChIKey: WPVQUWLESAWSRM-INIZCTEOSA-N
SMILES: C1(OC[C@@H]2CCN2)=CC(C#CC3=CC=CC=C3)=CN=C1
Biological Activity: VMY-2-95 is an oral active and blood-brain barrier (BBB) penetrant α4β2 nicotinic acetylcholine receptor desensitizer. VMY-2-95 can be used for study of depression or addiction[1][2].
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VMY-2-95 | VMY-2-95 is an oral active and blood-brain barrier (BBB) penetrant α4β2 nicotinic acetylcholine receptor desensitizer. VMY-2-95 can be used for study of depression or addiction. | |||||||||||||||||||||
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References
- [1]. Kong H, et al. Preclinical studies of the potent and selective nicotinic α4β2 receptor ligand VMY-2-95. Mol Pharm. 2015;12(2):393-402. [Content Brief]
- [2]. Yenugonda VM, et al. Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. J Med Chem. 2013;56(21):8404-8421. [Content Brief]
Keywords
