1441057-15-3
1441057-15-3
Chemical Structure
BMS-963272
- CAS No.: 1441057-15-3
- Formula:C24H21F6N5O2
- Molecular Weight:525.45
IUPAC Name: (S)-3-(1H-tetrazol-5-yl)-4-(p-tolyl)-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one
InChIKey: AEMPUAWUDAMJBV-QFIPXVFZSA-N
SMILES: CC1=CC=C(C2=C(C(N[C@@](C3=CC=C(C=C3)OCCCC(F)(F)F)(C(F)(F)F)C2)=O)C4=NN=NN4)C=C1
Biological Activity: BMS-963272 is an orally active and selective MGAT2 inhibitor (IC50 = 7.1 nM), used for the study of metabolic disorders and inflammatory diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-963272 | 99.02% | BMS-963272 is an orally active and selective MGAT2 inhibitor (IC50 = 7.1 nM), used for the study of metabolic disorders and inflammatory diseases. | ||||||||||||||||||||
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References
- [1]. Turdi H, et al. Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem. 2021 Oct 14;64(19):14773-14792. [Content Brief]
- [2]. Cheng D, et al. MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity. Cell Metab. 2022 Nov 1;34(11):1732-1748.e5. [Content Brief]
Keywords
