1445108-32-6
Chemical Structure
ER Tracker Yellow
Synonym(s): BDNCA-346
- CAS No.: 1445108-32-6
- Formula:C27H20BClF5N3O3
- Molecular Weight:575.72
IUPAC Name: (4aS,6R)-6-amino-N-((S)-1-(4-chlorophenyl)-3-hydroxypropyl)-4,4a,5,6,7,8-hexahydro-9H-3-oxa-1,8a,9,11-tetraazadibenzo[cd,f]azulene-6-carboxamide
InChIKey: KELQILVKLNLBAG-RMKNXTFCSA-N
SMILES: O=C(CCl)NC1=CC=C(C2=C3C(C)=CC(/C=C/C4=CC(OC(F)(F)F)=CC=C4O)=[N]3[B+3]([F-])([F-])[N-]5C=CC=C25)C=C1
Biological Activity: ER Tracker Yellow (BDNCA-346) is a Fluorescent probe for targeted visualization of temperature at the endoplasmic reticulum. Its detection mechanism depends on temperature, with fluorescence intensity decreasing at higher temperatures due to preferential non-radiative processes; this intensity reversibly returns to baseline when cooled, provided the probe does not precipitate or degrade. It localizes specifically to the endoplasmic reticulum, where it may covalently attach to biomacromolecules via a thiol-reactive moiety, and its fluorescence remains stable after cell fixation; its fluorescence intensity is unaffected by physiological pH ranges of 5.0–8.0 and free Ca²⁺ concentrations of 0–800 μM. Its excitation/emission wavelength is Ex/Em = 559/581 nm[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ER Tracker Yellow | 96.91% | ER Tracker Yellow (BDNCA-346) is a Fluorescent probe for targeted visualization of temperature at the endoplasmic reticulum. Its detection mechanism depends on temperature, with fluorescence intensity decreasing at higher temperatures due to preferential non-radiative processes; this intensity reversibly returns to baseline when cooled, provided the probe does not precipitate or degrade. It localizes specifically to the endoplasmic reticulum, where it may covalently attach to biomacromolecules via a thiol-reactive moiety, and its fluorescence remains stable after cell fixation; its fluorescence intensity is unaffected by physiological pH ranges of 5.0–8.0 and free Ca²⁺ concentrations of 0–800 μM. Its excitation/emission wavelength is Ex/Em = 559/581 nm. | ||||||||||||||||||||
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