1445383-14-1
Chemical Structure
ALS-8112-TP
- CAS No.: 1445383-14-1
- Formula:C10H16ClFN3O13P3
- Molecular Weight:533.62
IUPAC Name: ((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-(chloromethyl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: IMNKEHCKAWMCAU-IBCQBUCCSA-N
SMILES: O=P(OP(O)(O)=O)(O)OP(OC[C@]1(CCl)[C@@H](O)[C@@H](F)[C@H](N2C(N=C(C=C2)N)=O)O1)(O)=O
Biological Activity: ALS-8112-TP is the 5'-triphosphate metabolite of ALS-8112 (HY-12983). ALS-8112-TP is a potent, selective and competitive respiratory syncytial virus (RSV) RNA polymerase inhibitor, with selectivity against polymerases from host or viruses unrelated to RSV such as hepatitis C virus (HCV). ALS-8112-TP can be efficiently recognized by the recombinant RSV polymerase complex, causing chain termination of RNA synthesis. ALS-8112-TP can be used for RSV-infection research[1].
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ALS-8112-TP | ALS-8112-TP is the 5'-triphosphate metabolite of ALS-8112 (HY-12983). ALS-8112-TP is a potent, selective and competitive respiratory syncytial virus (RSV) RNA polymerase inhibitor, with selectivity against polymerases from host or viruses unrelated to RSV such as hepatitis C virus (HCV). ALS-8112-TP can be efficiently recognized by the recombinant RSV polymerase complex, causing chain termination of RNA synthesis. ALS-8112-TP can be used for RSV-infection research. | |||||||||||||||||||||
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Keywords
