1446324-02-2
1446324-02-2
Chemical Structure
MET kinase-IN-3
- CAS No.: 1446324-02-2
- Formula:C25H16ClF2N5O2
- Molecular Weight:491.88
IUPAC Name: 5-((4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)amino)-3-(4-fluorophenyl)-1,6-naphthyridin-4(1H)-one
InChIKey: VFFLZADJYBSNMH-UHFFFAOYSA-N
SMILES: NC1=NC=CC(OC2=C(C=C(C=C2)NC3=C4C(C(C5=CC=C(C=C5)F)=CNC4=CC=N3)=O)F)=C1Cl
Biological Activity: MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines[1].
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MET kinase-IN-3 | MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines. | |||||||||||||||||||||
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References
Keywords
