1446711-81-4
1446711-81-4
Chemical Structure
Acoramidis
Synonym(s): AG10
- CAS 番号: 1446711-81-4
- Formula:C15H17FN2O3
- Molecular Weight:292.31
IUPAC Name: 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid
InChIKey: WBFUHHBPNXWNCC-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(F)C(OCCCC2=C(C)NN=C2C)=C1
Biological Activity: Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Acoramidis | 98.47% | Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis. | ||||||||||||||||||||
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References
- [1]. Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. [Content Brief]
- [2]. Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129. [Content Brief]
Keywords
