145742-28-5
Chemical Structure
CP 122721
- CAS No.: 145742-28-5
- Formula:C20H23F3N2O2
- Molecular Weight:380.40
IUPAC Name: (2S,3S)-N-(2-methoxy-5-(trifluoromethoxy)benzyl)-2-phenylpiperidin-3-amine
InChIKey: ZIWFCOIGUNPHPM-HKUYNNGSSA-N
SMILES: FC(F)(F)OC1=CC=C(OC)C(CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)=C1
Biological Activity: CP 122721 is an orally active NK1 receptor antagonist. CP 122721 attenuates cisplatin-induced vomiting in ferrets (ID50: 0.08 mg/kg). CP 122721 inhibits kainate (KA)-induced seizure activity and CA1 neuronal cell death in rats. CP 122721 is useful in the study of depression, asthma, and irritable bowel syndrome (IBS)[1][2][3].
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CP 122721 | CP 122721 is an orally active NK1 receptor antagonist. CP 122721 attenuates cisplatin-induced vomiting in ferrets (ID50: 0.08 mg/kg). CP 122721 inhibits kainate (KA)-induced seizure activity and CA1 neuronal cell death in rats. CP 122721 is useful in the study of depression, asthma, and irritable bowel syndrome (IBS). | |||||||||||||||||||||
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- [1]. Gonsalves S, et al. Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets. Eur J Pharmacol. 1996 Jun 3;305(1-3):181-5. [Content Brief]
- [2]. Zachrisson O, Lindefors N, Brené S. A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity. Brain Res Mol Brain Res. 1998 Oct 1;60(2):291-5. [Content Brief]
- [3]. Duffy RA. Potential therapeutic targets for neurokinin-1 receptor antagonists. Expert Opin Emerg Drugs. 2004 May;9(1):9-21. [Content Brief]
Keywords
