1462951-30-9
1462951-30-9
Chemical Structure
EP009
- CAS No.: 1462951-30-9
- Formula:C14H24O2
- Molecular Weight:224.34
IUPAC Name: 2-(hydroxymethyl)-12-methylenecyclododecan-1-one
InChIKey: VHYYPGIKGAKBQI-UHFFFAOYSA-N
SMILES: O=C1C(CCCCCCCCCC1=C)CO
Biological Activity: EP009 is a JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation (IC50=10-20 μM in Kit225 cells) without affecting IL-3-induced JAK2 phosphorylation (up to 50 μM in BaF/3 cells). EP009 significantly reduced Kit225 cell viability (72 h, LD50=5.0 μM) while having no effect on BaF/3 cells.[1].
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EP009 | EP009 is a JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation (IC50=10-20 μM in Kit225 cells) without affecting IL-3-induced JAK2 phosphorylation (up to 50 μM in BaF/3 cells). EP009 significantly reduced Kit225 cell viability (72 h, LD50=5.0 μM) while having no effect on BaF/3 cells.. | |||||||||||||||||||||
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References
Keywords
