1476807-74-5
1476807-74-5
Chemical Structure
GAT107
- CAS No.: 1476807-74-5
- Formula:C18H17BrN2O2S
- Molecular Weight:405.31
IUPAC Name: (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
InChIKey: YNCXHXYZTLIZTO-HDMKZQKVSA-N
SMILES: O=S(C1=CC2=C(N[C@H](C3=CC=C(Br)C=C3)[C@@]4([H])[C@]2([H])C=CC4)C=C1)(N)=O
Biological Activity: GAT107 (compound 1b) is a potent α7 nAChR ago-PAMs (positive allosteric modulators)[1].
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GAT107 | GAT107 (compound 1b) is a potent α7 nAChR ago-PAMs (positive allosteric modulators). | |||||||||||||||||||||
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References
- [1]. Thakur GA, et al. Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors. J Med Chem. 2013 Nov 14;56(21):8943-7. [Content Brief]
Keywords
