1505453-59-7
Chemical Structure
BET bromodomain-IN-5
- CAS No.: 1505453-59-7
- Formula:C24H20ClN5O2
- Molecular Weight:445.90
IUPAC Name: (S)-2-(6-(4-chlorophenyl)-1-methyl-8-(1-methyl-1H-pyrazol-4-yl)-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
InChIKey: QFLGNZXBWIQDLQ-FQEVSTJZSA-N
SMILES: O=C(N)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=CC(C4=CN(C)N=C4)=CC=C3C5=C1ON=C5C
Biological Activity: BET bromodomain-IN-5 is an orally active BET inhibitor with an IC50 of 14 nM against BRD4 (1). BET bromodomain-IN-5 can inhibit the proliferation of tumor cells and induce cell cycle arrest and apoptosis. BET bromodomain-IN-5 can be used in the research of tumors[1][2].
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BET bromodomain-IN-5 | 99.49% | BET bromodomain-IN-5 is an orally active BET inhibitor with an IC50 of 14 nM against BRD4 (1). BET bromodomain-IN-5 can inhibit the proliferation of tumor cells and induce cell cycle arrest and apoptosis. BET bromodomain-IN-5 can be used in the research of tumors. | ||||||||||||||||||||
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- [1]. Andrew Ryan CONERY, et al. EXPRESSION LEVELS OF BCL-xL, BCL2, BCL-w, AND BAD AND CANCER THERAPIES. WO2015153871A2. 2015-10-08.
- [2]. Romero FA, et al. Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors. J Med Chem. 2016 Feb 25;59(4):1271-98. [Content Brief]
Keywords
