152753-94-1
Chemical Structure
5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite
- CAS No.: 152753-94-1
- Formula:C39H47N4O7PS
- Molecular Weight:746.85
IUPAC Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChIKey: LFZAXLODEUQTCY-LWVNILPLSA-N
SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5
Biological Activity: 5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
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5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite | 5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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