153504-81-5
153504-81-5
Chemical Structure
Licostinel
Synonym(s): ACEA-1021
- CAS No.: 153504-81-5
- Formula:C8H3Cl2N3O4
- Molecular Weight:276.04
IUPAC Name: 6,7-dichloro-5-nitro-1,4-dihydroquinoxaline-2,3-dione
InChIKey: CHFSOFHQIZKQCR-UHFFFAOYSA-N
SMILES: O=C1NC2=C(NC1=O)C([N+]([O-])=O)=C(C(Cl)=C2)Cl
Biological Activity: Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Licostinel | 98.12% | Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity. | ||||||||||||||||||||
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References
- [1]. Zhou ZL, et al. Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. [Content Brief]
- [2]. Albers GW, et al. Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke. 1999 Mar;30(3):508-13. [Content Brief]
- [3]. Martin H, et al. Effects of glycine receptor antagonism on spreading depression in the rat. Neurosci Lett. 1994 Oct 24;180(2):285-9. [Content Brief]
Keywords
