153587-01-0
153587-01-0
Chemical Structure
NS-1619
- CAS No.: 153587-01-0
- Formula:C15H8F6N2O2
- Molecular Weight:362.23
IUPAC Name: 1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
InChIKey: YLFMCMWKHSDUCT-UHFFFAOYSA-N
SMILES: O=C1NC2=CC(C(F)(F)F)=CC=C2N1C3=CC(C(F)(F)F)=CC=C3O
Biological Activity: NS-1619 is an opener of large conductance Ca2+-activated K+ (BK) channel. NS-1619 is a highly effective relaxant with an EC50 of about 10 – 30 μM in several smooth muscles of blood vessels and other tissues[1]. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NS-1619 | 98.06% | NS-1619 is an opener of large conductance Ca2+-activated K+ (BK) channel. NS-1619 is a highly effective relaxant with an EC50 of about 10 – 30 μM in several smooth muscles of blood vessels and other tissues. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. | ||||||||||||||||||||
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NS-1619 (Standard) | ≥98% | NS-1619 (Standard) is the analytical standard of NS-1619. This product is intended for research and analytical applications. NS-1619 is an opener of large conductance Ca2+-activated K+ (BK) channel. NS-1619 is a highly effective relaxant with an EC50 of about 10-30 μM in several smooth muscles of blood vessels and other tissues. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. | ||||||||||||||||||||
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References
- [1]. H Yamamura, et al. BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. Br J Pharmacol. 2001 Feb;132(4):828-34. [Content Brief]
- [2]. Xiaobing Han,et al. The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem Biophys Res Commun. 2008 Oct 17;375(2):205-9. [Content Brief]
