1541206-05-6
Chemical Structure
BU09059
- CAS. Nr.: 1541206-05-6
- Formula:C28H37N3O5
- Molecular Weight:495.61
IUPAC Name: ethyl 2-((R)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate
InChIKey: RKGRJMYCISUSNK-XTNINKNLSA-N
SMILES: C[C@]1(C2=CC(O)=CC=C2)[C@H](CN(CC(C(OCC)=O)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)CC1)C
Biological Activity: BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception[1].
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BU09059 | BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception. | |||||||||||||||||||||
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Keywords
