1562067-05-3
Chemical Structure
Banoxantrone-d12
Synonym(s): AQ4N d12
- CAS No.: 1562067-05-3
- Formula:C22H16D12N4O6
- Molecular Weight:456.55
IUPAC Name: 2,2'-((5,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)bis(azanediyl))bis(N,N-bis(methyl-d3)ethan-1-amine oxide)
InChIKey: YZBAXVICWUUHGG-MGKWXGLJSA-N
SMILES: O=N(C([2H])([2H])[2H])(C([2H])([2H])[2H])CCNC1=CC=C(NCCN(C([2H])([2H])[2H])(C([2H])([2H])[2H])=O)C(C(C2=C(O)C=CC(O)=C23)=O)=C1C3=O
Biological Activity: Banoxantrone-d12 is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
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Banoxantrone-d12 | Banoxantrone-d12 is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. | |||||||||||||||||||||
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Banoxantrone | Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation. | |||||||||||||||||||||
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Keywords
