158062-67-0
Chemical Structure
Flonicamid
Synonym(s): IKI220
- CAS No.: 158062-67-0
- Formula:C9H6F3N3O
- Molecular Weight:229.16
IUPAC Name: N-(cyanomethyl)-4-(trifluoromethyl)nicotinamide
InChIKey: RLQJEEJISHYWON-UHFFFAOYSA-N
SMILES: N#CCNC(C1=C(C(F)(F)F)C=CN=C1)=O
Biological Activity: Flonicamid (IKI220) is an antifeedant Insecticide active against Hemiptera, Thysanoptera, and piercing-sucking pests including aphids of all species, developmental stages and morphs. Flonicamid inhibits the inward rectifier potassium channel NlKir1, blocking stylet penetration, salivation, sap feeding, honeydew secretion, and fluid secretion by isolated Malpighian tubules. Flonicamid reduces renal excretory function in female Culex pipiens pallens. Flonicamid rapidly disrupts insect feeding behavior without neurotoxic poisoning symptoms, induces irreversible starvation, and increases the mortality of nymph progeny of adult aphids exposed to this agent[1][2].
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Flonicamid | 98.71% | Flonicamid (IKI220) is an antifeedant Insecticide active against Hemiptera, Thysanoptera, and piercing-sucking pests including aphids of all species, developmental stages and morphs. Flonicamid inhibits the inward rectifier potassium channel NlKir1, blocking stylet penetration, salivation, sap feeding, honeydew secretion, and fluid secretion by isolated Malpighian tubules. Flonicamid reduces renal excretory function in female Culex pipiens pallens. Flonicamid rapidly disrupts insect feeding behavior without neurotoxic poisoning symptoms, induces irreversible starvation, and increases the mortality of nymph progeny of adult aphids exposed to this agent. | ||||||||||||||||||||
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Flonicamid (Standard) | ≥98% | Flonicamid (Standard) (IKI220 (Standard)) is the analytical standard of Flonicamid (HY-119649). This product is intended for research and analytical applications. Flonicamid (IKI220) is an antifeedant Insecticide active against Hemiptera, Thysanoptera, and piercing-sucking pests including aphids of all species, developmental stages and morphs. Flonicamid inhibits the inward rectifier potassium channel NlKir1, blocking stylet penetration, salivation, sap feeding, honeydew secretion, and fluid secretion by isolated Malpighian tubules. Flonicamid reduces renal excretory function in female Culex pipiens pallens. Flonicamid rapidly disrupts insect feeding behavior without neurotoxic poisoning symptoms, induces irreversible starvation, and increases the mortality of nymph progeny of adult aphids exposed to this agent. | ||||||||||||||||||||
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Flonicamid-15N18O | 98.0% | Flonicamid-15N,18O (IKI220-15N,18O) is the 18O , 15N-labeled Flonicamid (HY-119649). Flonicamid (IKI220) is an antifeedant Insecticide active against Hemiptera, Thysanoptera, and piercing-sucking pests including aphids of all species, developmental stages and morphs. Flonicamid inhibits the inward rectifier potassium channel NlKir1, blocking stylet penetration, salivation, sap feeding, honeydew secretion, and fluid secretion by isolated Malpighian tubules. Flonicamid reduces renal excretory function in female Culex pipiens pallens. Flonicamid rapidly disrupts insect feeding behavior without neurotoxic poisoning symptoms, induces irreversible starvation, and increases the mortality of nymph progeny of adult aphids exposed to this agent. | ||||||||||||||||||||
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References
- [1]. Morita M, et al. Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding. Pest management science. 2007 Oct;63(10):969-73. [Content Brief]
- [2]. Ren M, et al. Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests. Insect biochemistry and molecular biology. 2018 Aug;99:17-26. [Content Brief]
