1581755-42-1
1581755-42-1
Chemical Structure
SARS-CoV-2 PLpro-IN-2
- CAS No.: 1581755-42-1
- Formula:C25H27ClN2O
- Molecular Weight:406.95
InChIKey: WYSVTAFOGXZFNZ-GOSISDBHSA-N
SMILES: C[C@@H](N1CCC(C(NCC2=CC=C(Cl)C=C2)=O)CC1)C3=CC=CC4=CC=CC=C43
Biological Activity: SARS-CoV-2 PLpro-IN-2 (Compound 12) is a highly selective SARS-CoV-2 papain-like protease (PLpro) inhibitor of (IC50=0.06 μM). SARS-CoV-2 PLpro-IN-2 inhibits viral replication and immune evasion. SARS-CoV-2 PLpro-IN-2 exhibits antiviral efficacy in HeLa-ACE2 cells (EC50=2.9 μM). SARS-CoV-2 PLpro-IN-2 is promising for research of COVID-19[1].
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SARS-CoV-2 PLpro-IN-2 | SARS-CoV-2 PLpro-IN-2 (Compound 12) is a highly selective SARS-CoV-2 papain-like protease (PLpro) inhibitor of (IC50=0.06 μM). SARS-CoV-2 PLpro-IN-2 inhibits viral replication and immune evasion. SARS-CoV-2 PLpro-IN-2 exhibits antiviral efficacy in HeLa-ACE2 cells (EC50=2.9 μM). SARS-CoV-2 PLpro-IN-2 is promising for research of COVID-19. | |||||||||||||||||||||
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References
Keywords
