1594121-16-0
Chemical Structure
SR-8993
- CAS No.: 1594121-16-0
- Formula:C25H37FN4
- Molecular Weight:412.59
IUPAC Name: (R)-1-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-2-(pyrrolidin-3-yl)-1H-benzo[d]imidazole
InChIKey: UTSJKSDPSCCJFP-HXUWFJFHSA-N
SMILES: FC1=CC=C2C(N=C([C@H]3CNCC3)N2C4CCN(CC5CCCCCCC5)CC4)=C1
Biological Activity: SR-8993 is a highly selective nociceptin receptor agonist that can penetrate the blood-brain barrier and has the activity of reducing alcohol intake and relieving withdrawal anxiety. SR-8993 has shown mild anxiolytic effects in animal models and can effectively reverse anxiety caused by acute alcohol withdrawal. SR-8993 further reduces restricted drinking, operant responses for alcohol, and increased drinking induced by long-term intermittent exposure to alcohol. SR-8993 also reduces stress- and cue-related alcohol-seeking relapse[1].
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SR-8993 | SR-8993 is a highly selective nociceptin receptor agonist that can penetrate the blood-brain barrier and has the activity of reducing alcohol intake and relieving withdrawal anxiety. SR-8993 has shown mild anxiolytic effects in animal models and can effectively reverse anxiety caused by acute alcohol withdrawal. SR-8993 further reduces restricted drinking, operant responses for alcohol, and increased drinking induced by long-term intermittent exposure to alcohol. SR-8993 also reduces stress- and cue-related alcohol-seeking relapse. | |||||||||||||||||||||
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Keywords
