1621482-36-7
1621482-36-7
Chemical Structure
8-Iso-15-keto prostaglandin F2β
- CAS No.: 1621482-36-7
- Formula:C20H32O5
- Molecular Weight:352.47
IUPAC Name: (Z)-7-((1S,2R,3R,5R)-3,5-dihydroxy-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
InChIKey: LOLJEILMPWPILA-WZDCOHRSSA-N
SMILES: OC(CCC/C=C\C[C@H]1[C@H]([C@@H](C[C@H]1O)O)/C=C/C(CCCCC)=O)=O
Biological Activity: 8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs[1][2].
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8-Iso-15-keto prostaglandin F2β | 8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs. | |||||||||||||||||||||
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References
- [1]. Janssen LJ, et al. Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles. Br J Pharmacol. 2001 Jan;132(1):127-34. [Content Brief]
- [2]. Janssen LJ, et al. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J Pharmacol Exp Ther. 2002 Jun;301(3):1060-6. [Content Brief]
Keywords
