163126-81-6
163126-81-6
Chemical Structure
Sepin-1
- CAS No.: 163126-81-6
- Formula:C9H9N3O4
- Molecular Weight:223.19
IUPAC Name: 2,2-dimethyl-5-nitro-2H-benzo[d]imidazole 1,3-dioxide
InChIKey: YLVSVJDCTDBERH-UHFFFAOYSA-N
SMILES: [O-][N+]1=C2C(C=C(C=C2)[N+]([O-])=O)=[N+](C1(C)C)[O-]
Biological Activity: Sepin-1 is a potent separase inhibitor with an IC50 value of 14.8 µM. Sepin-1 inhibits cell proliferation, migration and wound healing. Sepin-1 decreases the expression of FoxM1 protein and mRNA level. Sepin-1 shows anti-tumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sepin-1 | 99.29% | Sepin-1 is a potent separase inhibitor with an IC50 value of 14.8 µM. Sepin-1 inhibits cell proliferation, migration and wound healing. Sepin-1 decreases the expression of FoxM1 protein and mRNA level. Sepin-1 shows anti-tumor activity. | ||||||||||||||||||||
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References
- [1]. Zhang N, et al. Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth. J Cancer Sci Ther. 2018;10(3):517. [Content Brief]
- [2]. Zhang N, et al. Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J Biomol Screen. 2014 Jul;19(6):878-89. [Content Brief]
Keywords
